The very latest hybrid technology makes this model the most economical luxury saloon with a petrol engine, the hybrid technology makes fuel-efficient versions with a V6 or V8 engine. Mercedes-Benz S 400 HYBRID fuel consumption of 7.9 litres per 100 kilometres (NEDC combined) corresponds to carbon dioxide emissions of 186 grams per kilometre. The combined output is 220 kW/299 hp, with a combined maximum torque of 385 newton metres. The S 400 HYBRID accelerates to 100 km/h in 7.2 seconds and has a top speed of around 250 km/h.

The Mercedes-Benz S 400 Hybrid, 27 components with a total weight of just under 43 kilograms are produced with the use of natural materials.